Pharmacodynamic tetracycline is a broad-spectrum antibiotic of tetracycline, which has strong effects on Gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, Bacillus anthracis, Clostridium tetanus and Clostridium, but not as good as β-lactam. It is more sensitive to Gram-negative bacteria such as Escherichia coli, Salmonella, Brucella and Pasteurella, but not as sensitive as aminoglycosides and amidol antibiotics. It also inhibits Kettsiella, Mycoplasma, chlamydia, spirochetes, actinomycetes and some protozoa.
The apparent distribution volume of pharmacokinetic oxytetracycline was 2.1L/Kg in small animals, 1.4L/Kg in horses, and 0.8L/Kg in cattle. Oxytetracycline is mainly excreted by glomerular filtration in its original form. When renal function is impaired, the excretion slows down and the half-life is prolonged. The half-life of oxytetracycline was 10.5 hours for horses, 4.3 to 9.7 hours for cattle and 6.7 hours for pigs
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