Pharmacodynamics Ivermectin has good repellent action against in vivo and in vitro parasites mainly nematodes and arthropods. The mechanism of its repellent action is to promote the release of γ -aminobutyric acid (GABA) from presynaptic neurons, thus opening the GABA-mediated chloride channel. Ivermectin also has selectivity and high affinity for glutamate-mediated chloride channels located near gabA-mediated sites in nerves and muscle cells of invertebrates, thus interfering with neuromuscular signal transmission, causing relaxation and paralysis, resulting in death or excretion of the parasite. The inhibitory interneurons and excitatory motor neurons of nematodes are active sites, while the neuromuscular junctions of arthropods are active sites. The elimination rate of hemocellus, Osteriasis, Cuprimatodes, Strongylodes (including Strongylodes escherichia), rounded nematodes, stomatodes, nematodes, nematodes and chabotnematodes in sheep and cattle was 97% ~ 100%. It is also effective against arthropods, such as maggots, mites and lice. The effect on chewing lice and sheep tick fly is slightly worse. Ivermectin is also highly effective against ticks and flies that reproduce in their faeces. Although the drug does not kill ticks immediately, it can affect feeding, molting and oviposition, thus reducing the reproductive capacity of ticks. The effect on blood flies is similar. The removal rates of roundworm, Strongylodes rubosus, Strongylodes langerii, trichocephalus, oesophageal stomatodes, metastrongylodes, and adult and mature nematodes with odontocephalus were 94% ~ 100%. It was also very effective against trichinella spiralis in intestinal tract (but not against trichinella intramuscularis). It also had good control effect on blood louse and scabies. Not for flukes and tapeworms.
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